A step closer to determining the best sequential approach for treatment of BRAF-mutated metastatic melanoma?
Data from SECOMBIT provide useful insights to the optimal sequence of immune checkpoint inhibitor therapy and targeted treatment combinations for patients with BRAF-mutated, advanced melanoma
Immunotherapy confirmed as standard of care for melanoma brain metastases
Studies also suggest hope for TKI inhibitor combinations in patients with symptomatic brain metastases
Positive results with immunotherapy rechallenge in NSCLC
Results from the ATALANTE-1 and MRTX-500 trials show efficacy improvements with immunotherapy in patients post-immune checkpoint inhibitor failure
GORTEC-REACH study results fail to change the current standard of care for locally advanced SCCHN
Adding an immune checkpoint inhibitor to cetuximab plus radiotherapy does not improve outcomes versus standard of care in locally advanced squamous cell carcinoma of the head and neck
Upper GI tumours: survival benefits with PD-1 inhibitors plus chemotherapy, but not nivolumab plus ipilimumab
Phase III data highlight the consistent benefit of anti-PD-1 therapy for oesophageal and gastric cancer patients, with greatest benefit in high PD-L1-expressing tumours
The paradigm shift led by CDK4/6 inhibitors in breast cancer
The efficacy and overall good tolerability of cyclin-dependent kinase (CDK) 4/6 inhibitors have led to a change in the therapeutic algorithm of HR-positive/HER2-negative advanced breast cancer and established these compounds as the gold standard option for any patient with metastatic disease, except those with visceral crisis.
Positive early clinical results for amivantamab plus lazertinib in NSCLC
Two phase I trials in patients with advanced EGFR-mutated NSCLC demonstrate promising potential of targeted therapy with amivantamab plus lazertinib
Preclinical research offers promise of new CDK4/6 inhibitors
Positive in vitro and in vivo antitumour effects in breast and lung cancer models and in mismatch repair-driven cancer models
Switch maintenance with darolutamide shows promise in previously treated mCRPC
Significant, but clinically modest, prolongation of radiographic progression-free survival and event-free survival was achieved with darolutamide in the SAKK 08/16 study
Does perioperative chemotherapy improve outcomes in PDAC? Evidence is not yet conclusive
Trials provide insights into perioperative and adjuvant chemotherapy for resectable pancreatic cancer