Opinions

Findings from complex statistical modelling can form the basis for easy-to-use precision diagnostic and risk-stratification tools to help inform management decisions

Advances in spatial transcriptomics could provide novel opportunities for early detection, metastasis prediction and identification of actionable targets

Evidence from well-designed clinical trials is key to promote greater acceptance and access to palliative care

Evidence from tailored programmes in breast cancer show that a more holistic approach is needed to support patients to find the motivation to take up an active lifestyle 

High-quality studies employing molecular pathological epidemiology frameworks could help pinpoint aetiologic mechanisms and help tackle a potential future epidemic among the youngest 

While there has been significant progress in the development of these blood tests, hurdles remain including test sensitivity and false positives

Applications in artificial intelligence have the potential to transform precision oncology, but data quality and clinical validation of tools are still challenging

New data show that it does not increase the risk of breast cancer recurrence or development of secondary breast cancer in women, nor does it carry any health risks for the child

Extensive research identified the deficiency of a highly accurate DNA repair process known as homologous recombination as an ‘Achilles heel’ in cancer, and led to the development of PARP inhibitors as single-agent therapies 

Using treatments only where clear benefit has been demonstrated and modulating doses based on evidence are potentially effective strategies to reduce the rising costs of oncology