A pathway from air pollution to lung cancer in non-smokers has been identified
Lung and other thoracic tumours

A pathway from air pollution to lung cancer in non-smokers has been identified

In a study presented at ESMO Congress 2022, air pollution is shown to drive interleukin-1β release in cells with EGFR mutations to promote lung cancer development 

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TILs confirm to prolong PFS compared with immunotherapy in advanced melanoma
Cancer Immunology and Immunotherapy

TILs confirm to prolong PFS compared with immunotherapy in advanced melanoma

In a head-to-head comparison to the standard of care, tumour-infiltrating lymphocytes show clinical efficacy even in patients who are refractory to anti-PD-1 treatment 

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First positive phase III data for a gamma secretase inhibitor in desmoid tumours
Sarcomas

First positive phase III data for a gamma secretase inhibitor in desmoid tumours

Nirogacestat improves progression-free survival in a randomised trial performed in desmoid tumours 

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Adjuvant immunotherapy does not improve disease-free survival in renal cell carcinoma
Genitourinary cancers

Adjuvant immunotherapy does not improve disease-free survival in renal cell carcinoma

IMmotion010, CheckMate 914 and PROSPER miss their primary endpoints: back to square one for adjuvant immunotherapy? 

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Could anti-PD-L1 be the best choice as front-line therapy in platinum-ineligible patients with NSCLC?
Lung and other thoracic tumours

Could anti-PD-L1 be the best choice as front-line therapy in platinum-ineligible patients with NSCLC?

Findings show overall survival benefits with front-line atezolizumab versus single-agent chemotherapy, but questions remain regarding who might benefit 

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Don't miss

  • Molecular Analysis for Precision Oncology Congress 
    14-16 October 2022

EDITORIAL

Genitourinary cancers

Gastrointestinal cancers

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