Lenvatinib Plus Pembrolizumab Show Promise in Melanoma After Progression on Checkpoint Inhibitors
In the LEAP-004 study presented at the ESMO Virtual Congress 2020, ORR is encouraging but survival results are difficult to interpret.
Ovarian Cancer: First-line Dose-dense Chemotherapy is Not Superior to Standard 3-weekly Chemotherapy
ICON8 trial final analysis confirms results of the previously published progression-free survival analysis
Men and Women Benefit Differently from Immunotherapy
Understanding the impact of the patients’ sex on clinical outcomes to treatment with immunotherapy might add another piece to the puzzle of the most effective way to use checkpoint inhibitors.
Pembrolizumab Could Become a New Standard Option for Treatment of Kaposi Sarcoma
Encouraging early data suggests PD-1 blockade is also effective in other advanced non-melanoma skin cancers such as advanced basal cell carcinoma.
Are Higher Prices of Anticancer Medicines Reflected in Better Outcomes for Patients?
Studies presented at the ESMO Virtual Congress 2020 report high expenditure in the research and development process and discrepancies in costs of therapies among countries
PROfound: Overall Survival Data with Olaparib Herald Practice-changing Treatment of Metastatic Prostate Cancer
A new treatment paradigm for men with metastatic castration-resistant prostate cancer (mCRPC) and BRCA1, BRCA2 or ATM mutations
Surufatinib is a Potential New Option in Advanced Pancreatic NETs
Some studies presented at the ESMO Virtual Congress 2020 also show promise in addressing unmet needs in NETs, while a survey reveals delays in diagnosis or misdiagnosis are still common
How Does COVID-19 Impact on the Prognosis of Patients With Cancer?
Updates from three large global registries confirm that cancer is an independent adverse factor in people infected with coronavirus
Planned Thoracic Radiotherapy Has No Role in the Management of Completely Resected pN2 NSCLC
The LungART trial provides conclusive evidence that mediastinal post-operative radiotherapy should not be used routinely in these patients, and that radical surgery can remain a single local modality, to be followed by a watch-and-wait strategy
Preliminary Data for Two New Immunotherapy Targets Show Promise
Innovations focussing on the macrophage compartment with MK-4830 and on T-cell co-stimulation with PRS-343 demonstrate the continued benefits of translational research in oncology