Final results from the RADICALS-RT trial show that observation with salvage RT for prostate-specific antigen failure should be the current standard strategy after surgery
The SAPPHIRE trial failed to meet its primary endpoint compared with chemotherapy
Promising data from the ATTLAS phase III study indicate a potential new approach for treating patients progressing on TKIs
In the KEYNOTE-A18 study, the combination of pembrolizumab and concurrent chemoradiotherapy significantly improved progression-free survival
Adding immunotherapy to standard of care shows benefit compared with placebo and is confirmed to be practice-changing for this patient population
The impact of immunotherapy on disease progression and survival remains uncertain, but biomarker selection may be the future
Findings from the SANO trial also reported clinically complete responses after neoadjuvant chemoradiotherapy
Efficacy of PD-1 inhibitors in this setting reflects that reported in triple-negative breast cancer and is confirmed by long-term data presented at the ESMO Congress
Recently presented results suggest that a subset of patients with early stage rectal cancer could skip pre-operative radiotherapy, thus raising some questions about the standard of care
Regulatory, practical and economic challenges are associated with implementing this personalised treatment on a larger scale, thus currently limiting its availability and accessibility to patients
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