Second-line chemotherapy for advanced biliary tract provides modest efficacy but quality of life benefit
Standard second-line chemotherapy may benefit fit patients but efficacy is limited and new treatments are urgently needed
Standard second-line chemotherapy may benefit fit patients but efficacy is limited and new treatments are urgently needed
Encouraging efficacy data with anti-PD1 antibody in combination or as monotherapy
Thanks to remarkable advances, molecular analysis has taken central stage in the management of GIST, but there is still a need for less costly testing and further development of mitigation strategies to overcome resistance
The COSMIC-312 trial met its primary endpoint of progression-free survival, but interim overall survival results need further exploration
Knock-on effects of early immune checkpoint inhibitor use stimulate consideration of alternative approaches for further treatment lines
Risk assessment and alternative fluoropyrimidine regimens are the main changes in the Pan-Asian adapted ESMO Clinical Practice Guidelines, reinforcing ESMO’s commitment in the region
Phase III data highlight the consistent benefit of anti-PD-1 therapy for oesophageal and gastric cancer patients, with greatest benefit in high PD-L1-expressing tumours
Trials provide insights into perioperative and adjuvant chemotherapy for resectable pancreatic cancer
Good response rate and disease control with adagrasib and sotorasib in combination therapy shown in early-stage trials
Immune chemo-sensitisation results show potential for this approach in the treatment of advanced CRC, but greater understanding of response characteristics is required in future clinical trials
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