Adjuvant alectinib is a new treatment strategy for resected ALK-positive NSCLC
Alectinib is the first ALK inhibitor to significantly improve DFS in a phase III trial across disease stages
Alectinib is the first ALK inhibitor to significantly improve DFS in a phase III trial across disease stages
The bispecific EGFR/MET-directed monoclonal antibody looks set to become the standard of care in this setting, but toxicity has to be managed carefully
CheckMate 77T demonstrates significantly improved event-free survival with neoadjuvant nivolumab plus chemotherapy followed by adjuvant nivolumab compared with chemotherapy and adjuvant placebo
Safety and efficacy data of some novel immunotherapy agents are encouraging, but more research is needed to identify biomarkers and the optimal treatment schedule
Scarcity of prospective data was reported as well as a limited use of real-world evidence as definitive evidence to regulatory approval decisions of targeted therapies in Europe
Antitumour responses were consistent with those previously reported for a broader population of patients with advanced melanoma
Old and emerging traits of cancer provide a common set of principles that may help research shape future progress
Data from selected patients in the RUBY trial show improvements in QoL domains over the course of treatment and benefits compared with placebo
Results from studies presented at the ESMO Congress 2023 (Madrid, 20–24 October) outline different strategies involving indirect immune modulation and direct enhanced tumour cytotoxicity to improve on chemotherapy as the current standard of second-line care after ICI progression
Promising data from the ATTLAS phase III study indicate a potential new approach for treating patients progressing on TKIs
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