Whole-genome sequencing and single-cell sequencing can provide valuable insights not only in the identification of new therapy targets, but also to assess minimal residual disease and overcome treatment resistance
Newly-presented studies highlight that insights into cancer can also be unlocked from circulating tumour cells, exosomal microRNA and cell-free RNA
Among the presented findings, a potential role for ESR1 gene fusions was observed
Advances in spatial transcriptomics could provide novel opportunities for early detection, metastasis prediction and identification of actionable targets
Updated data from two studies report significant improvements in recurrence-free survival and distant-metastasis free survival with pembrolizumab or nivolumab
Novel treatment approaches show encouraging early results in solid tumours, but ways to boost precision immunotherapy are needed
Efficacy and safety of telisotuzumab adizutecan was investigated in patients with EGFR wild type non-squamous disease
Together with an off-trial use and off-track access to oncology therapies, a consolidated trend is reported in clinical practice despite the uncertainties on efficacy and safety
Evidence from well-designed clinical trials is key to promote greater acceptance and access to palliative care
The combination therapy with the CDK 4/6 inhibitor improved overall response rate compared to standard treatment
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