Claudin-targeted antibody–drug conjugates are promising treatments for solid tumours
According to results from several phase I trials, this precision oncology strategy also offers manageable safety
According to results from several phase I trials, this precision oncology strategy also offers manageable safety
Final overall survival data from the CONTACT-02 study are negative, but a survival advantage was observed with the novel combination in patients with liver or bone metastasis
Overall survival benefits of systemic therapy in the adjuvant setting are still unclear in clinical trials, and may need to be complemented with real-world studies
Preliminary results from three clinical trials reveal some benefits of cetuximab plus irinotecan, amivantamab plus FOLFOX or FOLFIRI and ramucirumab plus standard of care for patients with mCRC, including after progression on standard therapies
Applications in artificial intelligence have the potential to transform precision oncology, but data quality and clinical validation of tools are still challenging
Two studies report the results about the use of trastuzumab deruxtecan and androgen deprivation therapy for patients with this rare cancer
Studies reveal promising evidence for the more precise tailoring of immunotherapy and the role of AI in improving response evaluation
Results presented from some studies are a signal of an active area of research which is investigating not only immune checkpoint inhibitors but also vaccines and cellular therapies, although there are no immunotherapy treatments currently approved.
Three-year disease-free survival data from NICHE-2 and findings from NICHE-3 add to current knowledge on the benefits of immune checkpoint inhibition in this setting
Positive data presented from the LEAP-012 study for intermediate-stage disease, but it is still unclear how these will influence clinical practice
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