The efficacy and overall good tolerability of cyclin-dependent kinase (CDK) 4/6 inhibitors have led to a change in the therapeutic algorithm  of HR-positive/HER2-negative advanced breast cancer and established these compounds as the gold standard option for any patient with metastatic disease, except those with visceral crisis.

Two phase I trials in patients with advanced EGFR-mutated NSCLC demonstrate promising potential of targeted therapy with amivantamab plus lazertinib

Positive in vitro and in vivo antitumour effects in breast and lung cancer models and in mismatch repair-driven cancer models

Significant, but clinically modest, prolongation of radiographic progression-free survival and event-free survival was achieved with darolutamide in the SAKK 08/16 study

Trials provide insights into perioperative and adjuvant chemotherapy for resectable pancreatic cancer

Addition of abiraterone acetate plus prednisone shows clear survival improvements in castration-sensitive prostate cancer

Good response rate and disease control with adagrasib and sotorasib in combination therapy shown in early-stage trials

Results from the SAKK 01/10 trial demonstrate favourable progression-free survival and low toxicity with single-dose carboplatin and involved-node radiotherapy

Final overall survival results from the KEYNOTE-355 study confirm immune checkpoint inhibitors as the first-line treatment of choice in women with metastatic or relapsing disease