Reshaping the treatment landscape for GI cancers
ADCs are transforming the management of patients with GI cancers, but novel targets and combination strategies will be required to address resistance development and optimise patient outcomes
ADCs are transforming the management of patients with GI cancers, but novel targets and combination strategies will be required to address resistance development and optimise patient outcomes
New study findings provide support for the use of ctDNA to predict survival benefits and personalise treatments
The phase III KRYSTAL-10 trial did not meet its co-primary survival endpoints
An ATOMIC study pre-planned exploratory analysis reports no DFS benefit with the addition of immunotherapy in patients receiving fewer than six cycles of chemotherapy
Positive findings are reported for first-line zoldonrasib plus chemotherapy and second-line zoldonrasib plus daraxonrasib in two early-phase studies
Findings from the EMERALD-1 and EMERALD-3 studies suggest that further evidence of benefit is needed and to reflect on the use of surrogate endpoints
Tumours with no ctDNA-identified pathogenic variants for anti-EGFR drug resistance genes appear to respond to continued cetuximab beyond disease progression
Rapid advances in molecular targeting, immunotherapy optimisation and novel drug classes are reshaping gastrointestinal oncology
Every day, clinicians generate thousands of reports containing critical data that will never be analysed. Not because it lacks value — but because extracting it remains a bottleneck.
Testing standardisation and optimal integration for routine clinical use remain challenging
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