Immunotherapy is optimising outcomes in LACC, with durable responses and long-term survival, especially in those with immune activated or ‘hot’ tumours
Long-term dostarlimab data suggest that immunotherapy may be used with curative intent in this difficult-to-treat population
In advanced or metastatic disease, bulumtatug fuvedotin shows promising efficacy and manageable safety
Recent approvals are driving a shift toward biomarker-informed treatment strategies, rational combinations and personalised sequencing
In early-phase studies, two novel agents showed low propensity to induce heamatological toxicities in heavily pre-treated solid tumours
Multi-regional modelling reveals new ways to personalise treatments in gastric and breast cancers
A manageable safety profile was also reported for pumitamig plus the antibody-drug conjugate DB-1305/BNT325 in an early-phase study
Final results from the IMPACT study support screening measures, but open questions remain
Artificial intelligence is enabling a new class of biomarkers by integrating histology, molecular data, imaging, and clinical records to generate scalable, biologically grounded insights for precision oncology.
Integrating digital pathology with genomic and clinical data may enhance prediction of late recurrence and refine selection for adjuvant treatment intensification in HR-positive, HER2-negative disease
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