ESMO Sarcoma and Rare Cancers Congress 2023
![SARC_stage](/var/esmo/storage/images/media/esmo-daily-reporter/images/sarcoma-rare-cancers-2023/sarc_stage/17445446-1-eng-GB/sarc_stage_i770.jpg)
Promising advances in the molecular landscape of NETs
Molecular genetic analyses of NETs hint at actionable therapeutic targets and potential predictive biomarkers of response to axitinib
![Congress_audience_01](/var/esmo/storage/images/media/esmo-daily-reporter/images/generic-pictures-stock/congress_audience_01/9864550-1-eng-GB/congress_audience_01_i770.jpg)
Molecular characterisation of Ewing sarcomas could provide new treatment options for a patient subset
Activating EZH2 mutations may define a new subset of aggressive Ewing sarcomas that benefit from treatment with an EZH2 inhibitor
![Andrés Cervantes - Official 2023](/var/esmo/storage/images/media/esmo-daily-reporter/images/portraits/andres-cervantes-official-2023/17927117-1-eng-GB/andres-cervantes-official-2023_i770.jpg)
Improving patient involvement in rare cancers
Facilitating an open dialogue with patients, to better understand their needs, makes research efforts more valuable in the long-term
![Molecular profiling of neuroendocrine neoplasms reveals markers with prognostic and therapeutic relevance](/var/esmo/storage/images/esmo-daily-reporter/esmo-sarcoma-and-rare-cancers-congress-2023/news/molecular-profiling-of-neuroendocrine-neoplasms-reveals-markers-with-prognostic-and-therapeutic-relevance/17396162-5-eng-GB/molecular-profiling-of-neuroendocrine-neoplasms-reveals-markers-with-prognostic-and-therapeutic-relevance_i770.jpg)
Molecular profiling of neuroendocrine neoplasms reveals markers with prognostic and therapeutic relevance
A Spanish study describes the genomic characterisation of neuroendocrine neoplasms as the first step towards more personalised management
![Ornella Gonzato](/var/esmo/storage/images/media/esmo-daily-reporter/images/portraits/ornella-gonzato/17396342-1-eng-GB/ornella-gonzato_i770.jpg)
Patients as partners to address unmet needs in sarcoma
However, there are still many obstacles faced by investigators in achieving effective patient involvement in research
![New findings help guide management of appendix adenocarcinoma](/var/esmo/storage/images/esmo-daily-reporter/esmo-sarcoma-and-rare-cancers-congress-2023/esmo-sarcoma-and-rare-cancers-congress-2023/new-findings-help-guide-management-of-appendix-adenocarcinoma/17399483-1-eng-GB/new-findings-help-guide-management-of-appendix-adenocarcinoma_i770.jpg)
New findings help guide management of appendix adenocarcinoma
Database studies in this rare cancer suggest that chemotherapy may provide survival benefit in node-positive tumours and that the KRAS G12D mutation could be a potential therapeutic target
![SARC 2023_Proffered paper session](/var/esmo/storage/images/media/esmo-daily-reporter/images/sarcoma-rare-cancers-2023/sarc-2023_proffered-paper-session/17413409-1-eng-GB/sarc-2023_proffered-paper-session_i770.png)
Surgery remains the key to progression-free survival in ovarian sex cord-stromal tumours
Two studies presented by the French network TMRG-GINECO provide new insights into the treatment and quality of life of women with this rare cancer
![SARC 2023_Proffered paper session](/var/esmo/storage/images/media/esmo-daily-reporter/images/sarcoma-rare-cancers-2023/sarc-2023_proffered-paper-session2/17445497-1-eng-GB/sarc-2023_proffered-paper-session_i770.jpg)
Sinonasal cancer: whole-exome sequencing reveals potential therapeutic targets
Results from a study suggest that some existing inhibitors may benefit all subtypes of these rare malignancies, which currently lack effective treatments
![SARC 2023_Poster area](/var/esmo/storage/images/media/esmo-daily-reporter/images/sarcoma-rare-cancers-2023/sarc-2023_poster-area/17413604-1-eng-GB/sarc-2023_poster-area_i770.jpg)
Access to high-quality care for sarcomas is still unequal worldwide
Delays and poor patient journey are reported in resource-constrained countries, while awareness campaigns and healthcare service reorganisation have improved rare cancer management in more developed areas